Journal of Archives in Military Medicine
Volume:8 Issue: 2, Jun 2020

Context: 

The COVID-19 pandemic emerged in China and spread to the majority of countries worldwide, causing numerous health problems and restrictions on the people’s lifestyles. The complications of this disease can be much more severe in patients who have a weakened immune system or a chronic disease. Sickle cell disease is a genetic disorder in which the immune system is impaired. Exposure to COVID-19 will have severe consequences in the sickle cell disease patients. In this study aimed to investigate the relationship between this disease with the COVID-19 pandemic.

Evidence Acquisition:

 Embase, Scopus, Pub Med databases were reviewed. Keywords were combined as (“COVID19” OR “Coronavirus” AND “Anemia sickle Cell” OR “Sickle cell disease”). The results of related articles were used.

 At the time of the COVID-19 pandemic, chronic patients and those with weakened immune systems need to be more socially inclined to be less exposed to the COVID-19 virus.

 When producing the COVID vaccine, high-risk groups such as sickle cell anemia patients should be given priority.

Chronic wound healing remains a complicated issue in the world's scientific health society. Alterations in the human body conditions such as biochemical, immunological, and physiological states may lead to non-healing wounds, making the treatment an insurmountably long and expensive procedure. Diabetes mellitus disposes the body to many complicated conditions while preventing diabetic wounds away from the normal wound-healing process. As topical administration is a favorable route of treating wounds, here, in this article, different topical materials and their roles are briefly reviewed.

 Psychiatric disorders are common and impose a huge burden globally. The study aimed to examine the prevalence of psychiatric disorders in patients referring to a psychiatric clinic in Lorestan.

 This study aimed to investigate the prevalence of psychiatric disorders in patients referring to a psychiatric clinic in Lorestan province

 A cross-sectional study was conducted with all people aged 18 years or older. Participants were selected by a convenience sampling method. Diagnostic interviews based on DSM-5 were held for 750 patients who were administered between January and June 2018. The collected data were analyzed by SPSS version 22 using absolute frequency, relative frequency, mean, and chi-square test.

 Women included 53% of the study sample. The most prevalent psychiatric disorders were anxiety (35.3%) and mood disorders (31.5%). Depression was the most prevalent mood disorder (63.6%), followed by generalized anxiety disorder (60%). The prevalence of psychiatric disorders was higher in people aged 21-30 (28.5%), the illiterate or primary education group (52.4%), housekeepers (29.5%), and married ones (51.8%).

 The majority of the patients referring to the psychiatric clinic suffered from mood and anxiety disorders. Therefore, public health authorities of the province need to take steps to warrant necessary measures, including mental health promotion policies, to improve the mental health status and prevent anxiety and mood disorders.
 

 Laryngopharyngeal Reflux (LPR) is a condition in which gastric content reflux into the larynx and pharynx. It is one of the extraesophageal manifestations of gastroesophageal reflux disease (GERD), involving the laryngeal regio. The laryngopharyngeal epithelium is more susceptible to reflux-related tissue injury than the esophageal epithelium.

 This study aimed to test the hypothesis of whether severe vitamin D deficiency results in increased Laryngopharyngeal reflux (LPR) symptoms in Indian females. The objective was to find out the prevalence of LPR in the severe vitamin D deficient Indian female population.

 A descriptive observational study was done at a multispecialty polyclinic in New Delhi, India, over a period of one year. Based on a pilot study, a sample size of 185 individuals was taken. All females referring to the general outpatient department (OPD) with vitamin D levels below 20 ng/ml were included. The frequency of LPR symptoms in the study participants was assessed using the reflux symptom index (RSI) and reflux finding score (RFS) given for all symptomatic patients using a validated scoring system. The data were analyzed descriptively with Microsoft Excel and SPSS version 21 using appropriate tests.

 In this study, 92% of the subjects aged more than 25 years, and the mean vitamin D level was 9.87 (± 3.425) ng/ml. Moreover, 74% of study participants had severe vitamin D deficiency (≤ 10 ng/ml). The mean RSI for our study participants was 14.54 (± 10.353). Also, the mean RFS was 1.77 (± 3.069). No significant correlation was established between the severity of vitamin D deficiency and RSI as well as RFS. The prevalence of LPR was 43%.

 Hypovitaminosis D does not have any effect on LPR in the Indian female population.

 Implementing the post-activation potentiation phenomenon before a competition in the warm-up section may be better than performing the usual warm-up.

 Therefore, the purpose of this study was to determine the effects of type and intensity of muscle contraction with different recovery periods on anaerobic power and peak torque in young trained girls.

 Twelve female subjects (age: 22 ± 2.95 years; height: 165.42 ± 5.35 cm; weight: 57.33 ± 9.15 kg) who had at least two years of continuous training experience were randomly selected. The subjects performed the contraction protocols (isometric (3×70/7s), concentric (3 × 90/4), and eccentric (3 × 110/5)) or control conditions in eight sessions with at least 48 hours intervals between the sessions. In this study, the countermovement jump test and Biodex isokinetic device (60°.S-1) model (ISO-1) were used for measuring anaerobic power and maximum peak torque, respectively. Two-way repeated-measures ANOVA and one-way independent ANOVA were used for analyzing the data (P < 0.05).

 The between-group comparisons showed that the highest anaerobic power and peak torque values in immediate and three-minute recovery periods were seen in the concentric protocol, and the highest values in seven-minute recovery periods were seen in the eccentric protocol (P < 0.05). These variables were also significant in concentric and eccentric contractions in within-group comparisons (P < 0.05).

 Eccentric contraction, similar to other contractions, can produce PAP. It seems that eccentric contractions due to a higher intensity of contractions can maintain more consistency of PAP than do other contractions.

 Photodynamic Therapy (PDT) is considered as one of the alternative treatments for Head and Neck Squamous Cell Carcinoma (HNSCC). P53 mRNA is a tumor suppressor gene whose mutation increases the likelihood of uncontrolled cancer-like divisions. The mutation of CCND1 oncogenic increases the production of cyclin D1 as a tumorigenic protein.

 This study aimed to determine the effect of PDT using toluidine blue as a photosensitizer on the CCND1 and P53 mRNA levels in the HNSCC cell line.

 A human HNSCC cell line from NCBI.C196 designation HN5 was used. Cells were divided into four groups: Group I (HNSCC cell line under the influence of toluidine blue and laser irradiation), group II (HNSCC cell line under the influence of toluidine blue), group III (HNSCC cell line under laser irradiation), group IV (control group, HNSCC cell line). A 660 nm THOR laser using toluidine blue as a photosensitizer was applied. The RNA extraction was performed in three steps, including cell degradation, purification, and precipitation by alcohol. The cDNA was prepared using Takara Kit. The Amplicon kit and Real-Time PCR analysis were used for the assessment of mRNA relative levels.

 The P53 mRNA relative levels were 1.50 ± 0.33 in group I (P = 0.65), 1.49 ± 0.23 (P =0.5) in group II, and 1.40 ± 1.05 (P = 0.63) in group III. Compared to the control group, the mean increases in CCND1 mRNA were 18.01 ± 3.37 (p=0.04) in group I, 17.69 ± 3.3 (P = 0.03) in group II, and 9.01 ± 6.17 (P = 0.20) in group III.

 The comparison of the fold change index for P53 and CCND1 mRNA by the one-way ANOVA test showed that despite the increased expression of P53 and CCND1 mRNA in treatment groups compared to the control group, there was no statistically significant difference between the increases in P53 mRNA (P = 0.99) and CCND1 mRNA (P = 0.22) index between the groups. The results of this study could be a starting point for a better understanding of the mechanism of genes in PDT of the HNSCC cell line.